[The expression and significance of activator protein-1 and matrix metalloproteinases in the human heart post acute myocardial infarction].
Zhonghua Nei Ke Za Zhi
; 48(3): 205-7, 2009 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-19576087
OBJECTIVE: To investigate the expression and significance of activator protein-1 (AP-1) and matrix metalloproteinases (MMPs) in acute myocardial infarction (AMI) subjects. METHODS: Immunohistochemical techniques were used to detect the subunit of AP-1 (c-Jun), MMP-2 and MMP-9 in human AMI and normal heart tissue and the expressions of c-Jun and MMPs were measured with computer image analysis system. RESULTS: (1) There were expressions of c-Jun, MMP-2 and MMP-9 in normal heart tissue, mainly in myocardial cells and cardiac fibroblasts, and their expressions in AMI myocardial tissues were all significantly higher than those in normal myocardial tissues (P < 0.05). (2) The level of MMP-9 expression was significantly and positively correlated with c-Jun in AMI heart tissue (r = 0.773, P < 0.01). CONCLUSIONS: The expressions of AP-1 and MMPs increase in human myocardial infarction. These findings suggest that AP-1 transcription activation pathway and MMPs may play an important role in ventricular remodeling of myocardial infarction.
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Bases de datos:
MEDLINE
Asunto principal:
Factor de Transcripción AP-1
/
Metaloproteinasa 2 de la Matriz
/
Metaloproteinasa 9 de la Matriz
/
Infarto del Miocardio
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Año:
2009
Tipo del documento:
Article
País de afiliación:
China