Evolution of transcriptional regulatory circuits in bacteria.
Cell
; 138(2): 233-44, 2009 Jul 23.
Article
en En
| MEDLINE
| ID: mdl-19632175
ABSTRACT
Related organisms typically respond to a given cue by altering the level or activity of orthologous transcription factors, which, paradoxically, often regulate expression of distinct gene sets. Although promoter rewiring of shared genes is primarily responsible for regulatory differences among related eukaryotic species, in bacteria, species-specific genes are often controlled by ancestral transcription factors, and regulatory circuit evolution has been further shaped by horizontal gene transfer. Modifications in transcription factors and in promoter structure also contribute to divergence in bacterial regulatory circuits.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Bacterias
/
Regulación Bacteriana de la Expresión Génica
/
Evolución Molecular
/
Redes Reguladoras de Genes
Idioma:
En
Revista:
Cell
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos