Expression of E-cadherin, beta-catenin and topoisomerase IIalpha in leiomyosarcomas.
Clin Transl Oncol
; 11(8): 548-51, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19661031
ABSTRACT
INTRODUCTION:
The expression of E-cadherin, beta-catenin and topoisomerase II has been associated with clinical outcome of several cancers including sarcomas. We aimed to evaluate the expression of these markers in leiomyosarcomas (LMS). MATERIALS ANDMETHODS:
Paraffin blocks of 19 primary, nonmetastatic LMS were analysed immunohistochemically for the expression of the above-mentioned markers with a cutoff level for positivity of 20% of cell staining.RESULTS:
Expression of E-cadherin was negative in all LMS. Nuclear expression of beta-catenin was also negative in all cases, while positive cytoplasmic beta-catenin expression was observed in approximately half of the patients. The majority of LMS had expression of topoisomerase IIalpha, although only in 10 patients was this expression in more than 20% of tumour cells. From the analysed factors, tumour size was statistically significantly correlated with relapse-free survival.CONCLUSIONS:
Further evidence with larger series is required in order to determine the implication of these markers in LMS.
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Bases de datos:
MEDLINE
Asunto principal:
Cadherinas
/
ADN-Topoisomerasas de Tipo II
/
Proteínas de Unión al ADN
/
Beta Catenina
/
Leiomiosarcoma
/
Antígenos de Neoplasias
Límite:
Adult
/
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Transl Oncol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Grecia