Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorg Med Chem Lett
; 19(18): 5334-8, 2009 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-19683443
ABSTRACT
A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Na(v)1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement on Na(v)1.7 inhibitory activity.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dolor
/
Canales de Sodio
/
Bloqueadores de los Canales de Sodio
/
Isoxazoles
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos