Six-month outcome in acute kidney injury requiring renal replacement therapy in the ICU: a multicentre prospective study.

ABSTRACT

OBJECTIVE: To assess quality of life (QOL), mortality rate and renal function 6 months after onset of renal replacement therapy (RRT) for acute kidney injury (AKI) in the ICU. PARTICIPANTS AND SETTING: This prospective observational study was conducted in seven ICUs in France over 9 months. Inclusion criteria were age > or =18 years, RRT delivered for AKI and informed consent signed. AKI was defined from the RIFLE score. Recipients of kidney grafts or patients undergoing chronic RRT were not included. MEASUREMENTS AND RESULTS: QOL was assessed using the Short Form Health Survey (SF-36) questionnaire together with the Index of Activities of Daily Living (ADL) (0 full assistance to 6 no assistance). SF-36 was compared to a reference age- and sex-matched French population. Patient status, place of residence, and persistence of RRT, ADL and SF-36 were assessed at 28 days, 3 months and 6 months from inclusion. In the study period, 205 patients were included and 1 withdrew. At 6 months, 77/204 were alive (mortality 62%). SF-36 and ADL significantly increased from day 28 to 6 months. In the survivors at 6 months, SF-36 items were significantly lower than in the reference population, with the physical items more severely affected than the mental items; 64% were fully autonomous (ADL score = 6); 69% were living in their homes, and 12% were still undergoing RRT; 94% would agree to undergo the same management again. CONCLUSIONS: ICU survivors from RRT for AKI have an impaired QOL at 6 months, but sustained autonomy in their daily lives.