ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer.
J Leukoc Biol
; 86(5): 1075-87, 2009 Nov.
Article
en En
| MEDLINE
| ID: mdl-19745159
ABSTRACT
ABC transporters were identified originally for their contribution to clinical MDR as a result of their capacity to extrude various unrelated cytotoxic drugs. More recent reports have shown that ABC transporters can play important roles in the development, differentiation, and maturation of immune cells and are involved in migration of immune effector cells to sites of inflammation. Many of the currently identified, endogenous ABC transporter substrates have immunostimulating effects. Increasing the expression of ABC transporters on immune cells and thereby enhancing immune cell development or functionality may be beneficial to immunotherapy in the field of oncology. On the contrary, in the treatment of autoimmune diseases, blockade of these transporters may prove beneficial, as it could dampen disease activity by compromising immune effector cell functions. This review will focus on the expression, regulation, and substrate specificity of ABC transporters in relation to functional activities of immune effector cells and discusses implications for the treatment of cancer on the one hand and autoimmune diseases on the other.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Transportadoras de Casetes de Unión a ATP
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Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Leukoc Biol
Año:
2009
Tipo del documento:
Article