The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses.
Immunity
; 31(4): 677-89, 2009 Oct 16.
Article
en En
| MEDLINE
| ID: mdl-19833089
ABSTRACT
Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine balance at steady-state and the role of individual bacterial species in setting the balance remain elusive. Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficiently stimulate intestinal T cell responses. This function appeared the prerogative of a restricted number of bacteria, the prototype of which is the segmented filamentous bacterium, a nonculturable Clostridia-related species, which could largely recapitulate the coordinated maturation of T cell responses induced by the whole mouse microbiota. This bacterium, already known as a potent inducer of mucosal IgA, likely plays a unique role in the postnatal maturation of gut immune functions. Changes in the infant flora may thus influence the development of host immune responses.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ganglios Linfáticos Agregados
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Citocinas
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Clostridium
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Linfocitos T Reguladores
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Células TH1
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Intestinos
Límite:
Animals
Idioma:
En
Revista:
Immunity
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Francia