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Restoration of reversed whole PTH/intact PTH ratio and reduction in parathyroid gland vascularity during cinacalcet therapy for severe hyperparathyroidism in a uraemic patient.
Komaba, Hirotaka; Shin, Jeongsoo; Fukagawa, Masafumi.
Afiliación
  • Komaba H; Division of Nephrology and Kidney Center, Kobe University School of Medicine, Kobe 650-0017, Japan.
Nephrol Dial Transplant ; 25(2): 638-41, 2010 Feb.
Article en En | MEDLINE | ID: mdl-19892751
Parathyroid hormone (PTH) levels measured with the intact PTH assays are generally higher than those measured with the whole PTH assay; however, rare exceptions to this rule have been reported in patients with severe hyperparathyroidism associated with N-PTH overproduction. We report a haemodialysis patient with severe secondary hyperparathyroidism, in whom abnormally higher whole PTH levels than intact PTH levels were normalized during cinacalcet therapy. Moreover, we observed a marked reduction in parathyroid gland vascularity during this treatment. Our findings suggested that increased sensitivity of the parathyroid calcium sensing receptor by calcimimetics may modulate the secretion or truncation of N-PTH or other PTH molecules that can be detected by the whole PTH assay but not by the intact PTH assays.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hormona Paratiroidea / Glándulas Paratiroides / Hiperparatiroidismo / Naftalenos Límite: Humans / Male / Middle aged Idioma: En Revista: Nephrol Dial Transplant Asunto de la revista: NEFROLOGIA / TRANSPLANTE Año: 2010 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hormona Paratiroidea / Glándulas Paratiroides / Hiperparatiroidismo / Naftalenos Límite: Humans / Male / Middle aged Idioma: En Revista: Nephrol Dial Transplant Asunto de la revista: NEFROLOGIA / TRANSPLANTE Año: 2010 Tipo del documento: Article País de afiliación: Japón