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HMGCR gene polymorphism is associated with stroke risk in the EPIC-Norfolk study.
Freitas, Renata N; Khaw, Kay-Tee; Wu, Kelvin; Bowman, Richard; Jeffery, Hannah; Luben, Robert; Wareham, Nick J; Rodwell, Sheila.
Afiliación
  • Freitas RN; DENCS, School of Nutrition and NUPEB, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil. renata@enut.ufop.br
Eur J Cardiovasc Prev Rehabil ; 17(1): 89-93, 2010 Feb.
Article en En | MEDLINE | ID: mdl-19923996
ABSTRACT

BACKGROUND:

Earlier, a G/T single nucleotide polymorphism (SNP) in the HMGCR gene was shown to significantly reduce the overall serum lipids response to pravastatin. This study aimed to investigate the relationship of the rs17238540 SNP with coronary heart disease, stroke and cardiovascular disease risk.

DESIGN:

Cross-sectional study from the European Prospective Investigation into Cancer and Nutrition-Norfolk cohort.

METHODS:

Genotype was determined by pyrosequencing 23,011 participants, for whom clinical and biochemical data were available. Baseline risk factors according to genotype were evaluated, and the risk for fatal and nonfatal stroke, ischaemic heart disease and all types of cardiovascular diseases were assessed by logistic regression after approximately 11 years of follow-up.

RESULTS:

The G allele carriers presented 1.4 mmHg higher systolic blood pressure and 0.8 mmHg higher diastolic blood pressure than those who were TT carriers. They also presented higher risk of prevalent total (odds ratio 1.44, 95% confidence interval 1.05-1.97, P = 0.025) and nonfatal (odds ratio 1.56, 95% confidence interval 1.12-2.17, P = 0.009) stroke events compared with the TT individuals in the multivariate models.

CONCLUSION:

An association between the rs17238540 SNP and stroke risk was observed, independent of the effect of the SNP on the blood pressure. The possible mechanisms involved, besides the effect on blood pressure, might be related to pleiotropic functions of the HMGCR, and remain to be explored.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Polimorfismo de Nucleótido Simple / Hidroximetilglutaril-CoA Reductasas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Cardiovasc Prev Rehabil Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Polimorfismo de Nucleótido Simple / Hidroximetilglutaril-CoA Reductasas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Cardiovasc Prev Rehabil Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Brasil