Ischaemia-modified albumin in pulmonary hypertension.
Biomarkers
; 15(3): 238-42, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-19995310
ABSTRACT
BACKGROUND:
Pulmonary hypertension (PH) may be associated with subendocardial ischaemia. We investigated whether ischaemia-modified albumin (IMA), an established marker of ischaemia, is elevated in stable patients with PH.METHODS:
We studied 32 patients with PH and an equal number of age-matched normal volunteers. We assessed serum IMA levels with the albumin cobalt-binding test.RESULTS:
Patients' mean +/- SD (range) pulmonary arterial pressure was 56 +/- 12 (33-73) mmHg and their exercise capacity was 394 +/- 145 (121-688) m in the 6-min walk test. IMA was 92 +/- 14 (69-115) U ml(-1) in the patient group and 93 +/- 9.4 (76-122) U ml(-1) in the control group with no significant difference between the two (p = 0.85), although almost one-third of the patients had detectable troponin-I.CONCLUSIONS:
We conclude that IMA, a marker of ischaemia, does not differ in patients with advanced clinically stable PH compared with normal subjects.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Albúmina Sérica
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Isquemia Miocárdica
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Hipertensión Pulmonar
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biomarkers
Asunto de la revista:
BIOQUIMICA
Año:
2010
Tipo del documento:
Article