Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
Nat Genet
; 42(1): 24-6, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-20023658
ABSTRACT
We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Labio Leporino
/
Fisura del Paladar
/
Predisposición Genética a la Enfermedad
/
Estudio de Asociación del Genoma Completo
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Alemania