The future of non-human primate use in mAb development.
Drug Discov Today
; 15(5-6): 235-42, 2010 Mar.
Article
en En
| MEDLINE
| ID: mdl-20096369
ABSTRACT
It has been predicted that the use of non-human primates (NHPs) is going to increase considerably in the development of monoclonal antibodies (mAbs). Opportunities exist to focus on a rigorous, science-based approach to drug development, however, which will minimize this increase. In this article, the authors review current and future NHP use in mAb development based on surveys, experience and expert opinion and propose a framework that will minimize future NHP use and continue to support science and innovation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Modelos Animales de Enfermedad
/
Descubrimiento de Drogas
/
Anticuerpos Monoclonales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2010
Tipo del documento:
Article
País de afiliación:
Reino Unido