Efficient direct asymmetric vinylogous Michael addition reactions of gamma-butenolides to chalcones catalyzed by vicinal primary-diamine salts.
Chem Commun (Camb)
; 46(12): 2124-6, 2010 Mar 28.
Article
en En
| MEDLINE
| ID: mdl-20221513
ABSTRACT
The first direct organocatalytic asymmetric vinylogous Michael addition reactions of gamma-butenolides to chalcones have been developed by using chiral 1,2-diaminocyclohexane as a novel organocatalyst via a di-iminium transition state to provide syn-Michael products with good yields, high diastereoselectivities and enantioselectivities (up to 78% yield, >99 1 dr and 96% ee).
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
4-Butirolactona
/
Chalconas
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2010
Tipo del documento:
Article