A general and simple diastereoselective reduction by L-Selectride: efficient synthesis of protected (4S,5S)-dihydroxy amides.
Molecules
; 15(4): 2771-81, 2010 Apr 16.
Article
en En
| MEDLINE
| ID: mdl-20428078
ABSTRACT
A general approach to (4S,5S)-4-benzyloxy-5-hydroxy-N-(4-methoxybenzyl) amides 10 based on a diastereoselective reduction of (5S,6RS)-6-alkyl-5-benzyloxy-6-hydroxy-2-piperidinones 6 and their tautomeric ring-opened keto amides 7 is described. The reduction with L-Selectride at -20 degrees C to room temperature afforded the products 10 in excellent yields and moderate to high syn-diastereoselectivities.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Boranos
/
Amidas
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China