Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax.
Proc Natl Acad Sci U S A
; 107(23): 10638-43, 2010 Jun 08.
Article
en En
| MEDLINE
| ID: mdl-20479237
ABSTRACT
Cholera toxin (CT) elicits a mucosal immune response in mice when used as a vaccine adjuvant. The mechanisms by which CT exerts its adjuvant effects are incompletely understood. We show that protection against inhalation anthrax by an irradiated spore vaccine depends on CT-mediated induction of IL-17-producing CD4 Th17 cells. Furthermore, IL-17 is involved in the induction of serum and mucosal antibody responses by CT. Th17 cells induced by CT have a unique cytokine profile compared with those induced by IL-6 and TGF-beta, and their induction by CT requires cAMP-dependent secretion of IL-1beta and beta-calcitonin gene-related peptide by dendritic cells. These findings demonstrate that Th17 cells mediate mucosal adjuvant effects of CT and identify previously unexplored pathways involved in Th17 induction that could be targeted for development of unique mucosal adjuvants.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Toxina del Cólera
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Linfocitos T Colaboradores-Inductores
/
Vacunas contra el Carbunco
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos