Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.
Cancer Res
; 70(12): 4789-94, 2010 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-20501843
ABSTRACT
Cbl was originally discovered in 1989 as the cellular homolog of the v-Cbl oncogene, the transforming gene of the Cas NS-1 murine retrovirus that causes myeloid leukemia and lymphomas in mice. Cbl is a member of a family of RING finger ubiquitin ligases that negatively regulate signaling by tyrosine kinases and that function as adaptor proteins to regulate signaling positively. Until the past 2 years, there was little evidence that Cbl proteins were involved in human malignancies. Recent publications have shown homozygous mutations in Cbl in human myeloid neoplasms. Although in vitro and animal transformation models suggested that mutant forms of Cbl acted as an oncogene, the cellular role suggested that the protein could serve as a tumor suppressor gene. The recent data begin to reconcile this paradox as the loss of ubiquitin ligase function (the tumor suppressor function) is coupled to the maintenance of the positive signaling function (the oncogene function). These data also provide insight into potential therapeutic approaches to myeloid disorders harboring Cbl mutations.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Leucemia Mieloide
/
Proteínas Proto-Oncogénicas c-cbl
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos