Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.
J Comb Chem
; 12(5): 687-95, 2010 Sep 13.
Article
en En
| MEDLINE
| ID: mdl-20578711
ABSTRACT
Cathepsin V is a papain-like cysteine protease. It is involved in the control of human T cells (responsible for cell immunity), and presents the largest elastolytic activity among the proteolytic enzymes. Therefore, cathepsin V is a potential molecular target for the treatment of atherosclerosis. In the present work, natural flavonoids were screened against cathepsin V, and two flavones were identified as potent inhibitors of cathepsin V. On the basis of this result, a combinatorial library of chalcones and flavones was prepared, in solution phase employing a scavenger reagent, and fully evaluated.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Catepsinas
/
Inhibidores de Cisteína Proteinasa
/
Técnicas Químicas Combinatorias
/
Chalconas
/
Flavonas
Límite:
Humans
Idioma:
En
Revista:
J Comb Chem
Asunto de la revista:
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil