Modafinil administration improves working memory in methamphetamine-dependent individuals who demonstrate baseline impairment.
Am J Addict
; 19(4): 340-4, 2010.
Article
en En
| MEDLINE
| ID: mdl-20653641
ABSTRACT
Modafinil improves working memory in healthy subjects and individuals diagnosed with schizophrenia and Attention Deficit/Hyperactivity Disorder, though the effects of modafinil have not been evaluated on working memory in methamphetamine-dependent subjects. This double-blind, placebo-controlled study evaluated whether a daily dose of 400 mg of modafinil, administered over three consecutive days, would enhance performance on a measure of working memory relative to test performance at baseline and following 3 days of placebo administration in 11 methamphetamine addicted, nontreatment-seeking volunteers. The results revealed that participants demonstrating relatively poor performance on the third day of a 3-day washout period (ie, at baseline), showed significant improvement on measures of working memory, but not on measures of episodic memory or information processing speed. In contrast, for participants demonstrating relatively high performance at baseline, modafinil administration did not affect test scores. The findings provide an initial indication that modafinil can reverse methamphetamine-associated impairments in working memory.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos de Bencidrilo
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Trastornos Relacionados con Anfetaminas
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Estimulantes del Sistema Nervioso Central
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Memoria a Corto Plazo
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Am J Addict
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos