Biaryl substituted hydantoin compounds as TACE inhibitors.
Bioorg Med Chem Lett
; 20(17): 5286-9, 2010 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-20663669
ABSTRACT
We disclose further optimization of hydantoin TNF-alpha convertase enzyme (TACE) inhibitors. SAR with respect to the non-prime region of TACE active site was explored. A series of biaryl substituted hydantoin compounds was shown to have sub-nanomolar K(i), good rat PK, and good selectivity versus MMP-1, -2, -3, -7, -9, and -13.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores Enzimáticos
/
Proteínas ADAM
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos