Identification of new pathogens in the intraocular fluid of patients with uveitis.
Am J Ophthalmol
; 150(5): 628-36, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-20691420
ABSTRACT
PURPOSE:
To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis.DESIGN:
Case-control study.METHODS:
Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by polymerase chain reaction and/or antibody analysis in intraocular fluids, were assessed for the presence of 18 viruses and 3 bacteria by real-time polymerase chain reaction (PCR). The ocular fluids from 48 patients with uveitis of known etiology or with cataract were included as controls.RESULTS:
Positive PCR results were found for Epstein-Barr virus, for rubella virus, and for human herpesvirus 6 each in 1 patient and for human parechovirus in 4 patients. Of the human parechovirus-positive patients, 1 was immunocompromised and had panuveitis. The other 3 patients were immunocompetent and had anterior uveitis, all with corneal involvement.CONCLUSIONS:
Human parechovirus might be associated with infectious (kerato)uveitis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Humor Acuoso
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Virus de la Rubéola
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Infecciones Virales del Ojo
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Uveítis Anterior
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Herpesvirus Humano 6
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Herpesvirus Humano 4
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Parechovirus
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Ophthalmol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Países Bajos