Toxicity to Chinese hamster ovary (CHO) cells of the products of reaction of butylated hydroxyanisole with nitrite at low pH.
Toxicol In Vitro
; 8(1): 117-23, 1994 Feb.
Article
en En
| MEDLINE
| ID: mdl-20692896
ABSTRACT
Butylated hydroxyanisole (BHA) was found to react readily with nitrite in acidified physiological saline. With low concentrations of reactants at pH 2, HPLC analysis demonstrated the formation of two products, tert-butylquinone (BQ) and a second, unidentified compound. Neutralized BHA/nitrite reaction mixtures were highly toxic to cultured Chinese hamster ovary (CHO) cells. At non-lethal concentrations, causing some cell cycle delay, there was a statistically significant but variable induction of endoreduplication and tetraploidy and a very weak induction of chromosome breakage. The effects were similar to those of pure BQ. It is suggested that the formation of toxic products from BHA, by an oxidative reaction such as that described with nitrite, might be involved in the mechanism of BHA carcinogenesis in the rat forestomach.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Toxicol In Vitro
Asunto de la revista:
TOXICOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Reino Unido