[Benzisoselenazolinones and their derivatives, a new series of anti-inflammatories and antioxidants]. / Les benzisosélénazolinones et leurs dérivés, nouvelle série d'antiinflammatoires et d'antioxydants.

ABSTRACT

Ebselen, a benzisoselenazolinone, displays antiinflammatory properties and antioxidant capacity similar to the enzyme glutathione peroxydase. Structural modifications were realized. The presence of substituents ortho to selenium, and in particular of a dipolar group such as -NO2, led to an interesting modification of the pharmacological properties.