The cytoskeleton coordinates the early events of B-cell activation.
Cold Spring Harb Perspect Biol
; 3(2)2011 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-21047917
ABSTRACT
B cells contribute to protective adaptive immune responses through generation of antibodies and long-lived memory cells, following engagement of the B-cell receptor (BCR) with specific antigen. Recent imaging investigations have offered novel insights into the ensuing molecular and cellular events underlying B-cell activation. Following engagement with antigen, BCR microclusters form and act as sites of active signaling through the recruitment of intracellular signaling molecules and adaptors. Signaling through these "microsignalosomes" is propagated and enhanced through B-cell spreading in a CD19-dependent manner. Subsequently, the mature immunological synapse is formed, and functions as a platform for antigen internalization, enabling the antigen presentation to helper T cells required for maximal B-cell activation. In this review, we discuss the emerging and critical role for the cytoskeleton in the coordination and regulation of these molecular events during B-cell activation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Citoesqueleto
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Linfocitos B
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Activación de Linfocitos
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Receptores de Antígenos de Linfocitos B
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Transducción de Señal
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Inmunidad Adaptativa
Límite:
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Biol
Asunto de la revista:
BIOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido