ß-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity.
J Nat Prod
; 73(12): 1993-8, 2010 Dec 27.
Article
en En
| MEDLINE
| ID: mdl-21090796
ABSTRACT
The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 ß-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 µM.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Carbolinas
/
Antiinflamatorios no Esteroideos
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Stellaria
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Alcaloides
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2010
Tipo del documento:
Article
País de afiliación:
China