Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder.
Mol Genet Metab
; 102(2): 149-52, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21093335
ABSTRACT
Mitochondrial DNA (mtDNA) depletion syndromes are autosomal recessive conditions in which the mtDNA copy number is greatly decreased in affected tissues. The encephalomyopathic group of these syndromes comprise mutations in SUCLA2 and SUCLG1 subunits [1]. In this report, we describe a patient with fatal infantile lactic acidosis associated with mutations in the SUCLG1 gene and mtDNA depletion. Histological and enzymatic abnormalities in skeletal muscle support the diagnosis of this recently described mitochondrial disorder. This case is unique in that prenatal imaging suggested the diagnosis and that the confirmatory molecular diagnosis was established at 2 weeks of age. We describe prenatal MRI and neonatal laboratory disturbances that can point the clinician toward consideration of this diagnosis when treating infantile lactic acidosis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Succinato-CoA Ligasas
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Acidosis Láctica
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ADN Mitocondrial
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Enfermedades Mitocondriales
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Mutación
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
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Newborn
/
Pregnancy
Idioma:
En
Revista:
Mol Genet Metab
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
METABOLISMO
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos