Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.
Bioorg Med Chem Lett
; 21(1): 492-6, 2011 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-21094606
ABSTRACT
Small molecule isoindoline and tetrahydroisoquinoline derivatives have been identified as selective agonists of human peroxisome proliferator-activated receptor δ (PPARδ. Compound 18 demonstrated efficacy in a biomarker for increased fatty acid oxidation, with upregulation of pyruvate dehydrogenase kinase, isozyme 4 (PDK4) in human primary myotubes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tetrahidroisoquinolinas
/
PPAR delta
/
Indoles
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido