Synonymous but not the same: the causes and consequences of codon bias.
Nat Rev Genet
; 12(1): 32-42, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-21102527
ABSTRACT
Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology. Although recent advances in sequencing and synthetic biology have helped to resolve longstanding questions about codon bias, they have also uncovered striking patterns that suggest new hypotheses about protein synthesis. Ongoing work to quantify the dynamics of initiation and elongation is as important for understanding natural synonymous variation as it is for designing transgenes in applied contexts.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Codón
/
Genoma
/
Mutación
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos