Small RNA sorting: matchmaking for Argonautes.
Nat Rev Genet
; 12(1): 19-31, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-21116305
ABSTRACT
Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells. To perform their myriad roles, not only must precise small RNA species be generated, but they must also be loaded into specific effector complexes called RNA-induced silencing complexes (RISCs). Argonaute proteins form the core of RISCs and different members of this large family have specific expression patterns, protein binding partners and biochemical capabilities. In this Review, we explore the mechanisms that pair specific small RNA strands with their partner proteins, with an eye towards the substantial progress that has been recently made in understanding the sorting of the major small RNA classes - microRNAs (miRNAs) and small interfering RNAs (siRNAs) - in plants and animals.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Factores Eucarióticos de Iniciación
/
MicroARNs
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Genet
Asunto de la revista:
GENETICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos