Quinolones as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 21(1): 82-7, 2011 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-21145235
ABSTRACT
Hepatitis C virus (HCV) infection is treated with a combination of peginterferon alfa-2a/b and ribavirin. To address the limitations of this therapy, numerous small molecule agents are in development, which act by directly affecting key steps in the viral life-cycle. Herein we describe our discovery of quinolone derivatives, novel small-molecules that inhibit NS5b polymerase, a key enzyme of the viral life-cycle. A crystal structure of a quinoline analog bound to NS5B reveals that this class of compounds binds to allosteric site-II (non-nucleoside inhibitor-site 2, NNI-2) of this protein.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Proteínas no Estructurales Virales
/
Hepacivirus
/
Quinolonas
/
Inhibidores Enzimáticos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos