Procedural learning impairments identified via predictive saccades in chronic traumatic brain injury.
Cogn Behav Neurol
; 23(4): 210-7, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-21150346
ABSTRACT
OBJECTIVE:
To characterize integrity of fronto-striatal circuitry in chronic traumatic brain injury (TBI).BACKGROUND:
Due to both direct and indirect effects, TBI is hypothesized to affect frontal and striatal function. On the basis of elegant animal, lesion, and neuroimaging literatures, oculomotor testing can provide a useful tool for in vivo assessments of neurophysiologic function. The predictive saccade paradigm in oculomotor function is well established to provide assessment of this fronto-striatal circuit.METHODS:
Sixty patients with a history of chronic TBI completed 2 specific tests of oculomotor function, including a test of reflexive visually guided saccades to assess basic oculomotor function and a predictive saccade test to assess procedural learning.RESULTS:
TBI (mild and moderate/severe) was associated with a decrease in rates of procedural learning, with degree of impairment increasing with injury severity. This was observed as a decrease in the proportion of anticipatory saccades (primary measure of learning).CONCLUSIONS:
This abnormal oculomotor performance supports the hypothesis that TBI results in chronic impairment of frontal-striatal functions proportionally to injury severity and demonstrate that oculomotor testing is sensitive to all severities of closed-head injury.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Movimientos Sacádicos
/
Lesiones Encefálicas
/
Lesión Encefálica Crónica
/
Discapacidades para el Aprendizaje
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cogn Behav Neurol
Asunto de la revista:
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos