The Parkinson disease protein α-synuclein inhibits autophagy.
Autophagy
; 7(4): 429-31, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21157184
ABSTRACT
Parkinson disease (PD) is the most common movement disorder affecting people. It is characterized by the accumulation of the protein α-synuclein in Lewy body inclusions in vulnerable neurons. α-Synuclein overexpression caused by gene multiplications is sufficient to cause this disease, suggesting that α-synuclein accumulation is toxic. Here we review our recent study showing that α-synuclein inhibits autophagy. We discuss our mechanistic understanding of this phenomenon and also speculate how a deficiency in autophagy may contribute to a range of pleiotropic features of PD biology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Autofagia
/
Alfa-Sinucleína
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Autophagy
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido