Up-regulation of the vitamin C transporter SVCT2 upon differentiation and depolarization of myotubes.
FEBS Lett
; 585(2): 390-6, 2011 Jan 21.
Article
en En
| MEDLINE
| ID: mdl-21176777
ABSTRACT
In addition to its role as a strong antioxidant, vitamin C regulates the differentiation of several cell lineages. In vertebrate skeletal muscle, the vitamin C transporter SVCT2 is preferentially expressed in slow muscle fibers. To gain insights into the possible involvement of intracellular vitamin C on early myogenesis, we investigated the regulation of SVCT2 expression in cultures of chick fetal myoblasts. SVCT2 expression increases in cultures of both, slow and fast muscle-derived myoblasts, as they fuse to form mainly fast myotubes. Interestingly, we found that SVCT2 could be positively modulated by potassium-induced depolarization of myotubes. These findings suggest that SVCT2-mediated uptake of vitamin C could play diverse roles on skeletal muscle development and physiology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
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Regulación hacia Arriba
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Fibras Musculares Esqueléticas
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Transportadores de Anión Orgánico Sodio-Dependiente
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Simportadores
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
2011
Tipo del documento:
Article
País de afiliación:
Chile