Hypofibrinolysis associated with vasculopathy in non insulin dependent diabetes mellitus.
Thromb Res
; 59(1): 51-9, 1990 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-2119076
ABSTRACT
The pathogenesis of diabetic vasculopathy has been related to modifications in hemostasis and fibrinolysis. 50 non insulin dependent diabetes mellitus patients have been studied. Euglobulin clot lysis time, fibrin plate, tissue plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PAI) activity, Protein C and S, cholesterol, triglycerides and Hb A1c were determined in blood samples. Diabetic patients showed decreased fibrinolytic activity, as measured by ECLT, with clearly increased PAI levels. Fibrinolytic response to venous occlusion was lower than normal. Vascular complications were associated both with an even higher PAI activity and with a decreased fibrinolytic response to venous occlusion. Elevated PAI activity and decreased fibrinolytic response to stimulus may contribute to vascular disease in diabetes.
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Bases de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
/
Angiopatías Diabéticas
/
Fibrinólisis
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Thromb Res
Año:
1990
Tipo del documento:
Article
País de afiliación:
España