Successful treatment of sepsis-induced disseminated intravascular coagulation in a patient with idiopathic thrombocytopenic purpura using recombinant human soluble thrombomodulin.
Rheumatol Int
; 31(12): 1657-9, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21240494
ABSTRACT
Disseminated intravascular coagulation (DIC) may complicate a variety of disorders that contribute to mortality, particularly those related to bleeding. It is therefore very difficult to manage DIC in patients with known bleeding disorders. We treated a 62-year-old woman with idiopathic thrombocytopenic purpura (ITP) complicated with sepsis-induced DIC. She had been diagnosed with ITP 8 months prior to admission. Laboratory tests showed an elevation of d-dimer and endotoxin, while pyelonephritis was shown by abdominal computed tomography. Escherichia coli was detected by blood culture. Based on these findings, the patient was diagnosed with sepsis-induced DIC due to urinary tract infection. Thrombocytopenia was refractory despite the use of antibiotics and platelet transfusion, but it was promptly improved in response to recombinant human soluble thrombomodulin (rTM). We suggest that rTM provides a new therapeutic strategy for DIC patients with high hemorrhagic risk.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas Recombinantes
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Púrpura Trombocitopénica Idiopática
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Trombomodulina
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Sepsis
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Coagulación Intravascular Diseminada
Tipo de estudio:
Diagnostic_studies
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Rheumatol Int
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón