Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation.
FEBS Lett
; 585(4): 630-4, 2011 Feb 18.
Article
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| MEDLINE
| ID: mdl-21251910
ABSTRACT
LEA (late embryogenesis abundant) proteins are intrinsically disordered proteins that contribute to stress tolerance in plants and invertebrates. Here we show that, when both plant and animal LEA proteins are co-expressed in mammalian cells with self-aggregating polyglutamine (polyQ) proteins, they reduce aggregation in a time-dependent fashion, showing more protection at early time points. A similar effect was also observed in vitro, where recombinant LEA proteins were able to slow the rate of polyQ aggregation, but not abolish it altogether. Thus, LEA proteins act as kinetic stabilisers of aggregating proteins, a novel function in protein homeostasis consistent with a proposed role as molecular shields.
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Bases de datos:
MEDLINE
Asunto principal:
Péptidos
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Proteínas de Plantas
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Proteínas del Helminto
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Chaperonas Moleculares
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Homeostasis
Límite:
Animals
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Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2011
Tipo del documento:
Article