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A synthesis of acetamidines.
Harjani, Jitendra R; Liang, Chen; Jessop, Philip G.
Afiliación
  • Harjani JR; Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada.
J Org Chem ; 76(6): 1683-91, 2011 Mar 18.
Article en En | MEDLINE | ID: mdl-21314093
The condensation of primary amine with N,N-dimethylacetamide dimethyl acetal yields a mixture of acetamidine and imidate ester. The product distribution in this reaction depends on the temperature, solvent, and structure of the primary amine. It is possible to suppress the formation of imidate ester by performing the reaction in the presence of excess dimethyl amine, yielding acetamidine as the exclusive product. For acetamidines that cannot be purified either by crystallization or distillation, this new method is necessary for the generation of pure acetamidines in good yields.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Amidinas Idioma: En Revista: J Org Chem Año: 2011 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Amidinas Idioma: En Revista: J Org Chem Año: 2011 Tipo del documento: Article País de afiliación: Canadá