Effect of vascular endothelial growth factor 121 adenovirus transduction in rabbit model of femur head necrosis.
J Trauma
; 70(6): 1519-23, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21336201
ABSTRACT
BACKGROUND:
Our objective was to observe the role of vascular endothelial growth factor (VEGF) 121 gene transfer in promoting vascular reconstruction and bone repair in femur head necrosis of rabbits.METHODS:
The femoral head necrosis model was induced by injection with ethanol. The necrotic femoral head was transfected with a human adenoviral vector expressing VEGF (Ad-hVEGF121). Bone formation in the subchondral necrotic region was analyzed using histology, by measuring the bone mineral density value, and by observing bone trabecular morphology using image analysis.RESULTS:
Revascularization level, bone formation rate, bone quality and quantity, and mineralization level in the subchondral necrotic region of the gene transfection group were significantly higher than the control groups. The control groups had more subchondral bone resorption compared with the gene transfection group.CONCLUSION:
VEGF might promote bone formation and revascularization in the subchondral necrotic region of the femoral head, indirectly protecting the necrotic bone trabecula from absorption and avoiding a reduction in the mechanical function of the subchondral region.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Osteogénesis
/
Factor A de Crecimiento Endotelial Vascular
/
Necrosis de la Cabeza Femoral
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Trauma
Año:
2011
Tipo del documento:
Article
País de afiliación:
China