Lack of association of herpes simplex virus type 2 seropositivity with the progression of HIV infection in the HERS cohort.
Am J Epidemiol
; 173(7): 837-44, 2011 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-21372062
ABSTRACT
Many studies have chronicled the "epidemiologic synergy" between human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2). HIV adversely affects the natural history of HSV-2 and results in more frequent and severe HSV-2 reactivation. Few longitudinal studies, however, have examined whether HSV-2 is associated with increased HIV plasma viral loads or decreased CD4 counts. The authors estimated the effect of HSV-2 seropositivity on HIV RNA viral load and on CD4 count over time among 777 HIV-seropositive US women not receiving suppressive HSV-2 therapy in the HIV Epidemiology Research Study (1993-2000). Linear mixed models were used to assess the effect of HSV-2 on log HIV viral load and CD4 count/mm(3) prior to widespread initiation of highly active antiretroviral therapy. Coinfection with HSV-2 was not associated with HIV RNA plasma viral loads during study follow-up. There was a statistically significant association between HSV-2 seropositivity and CD4 count over time, but this difference was small and counterintuitive at an increase of 8 cells/mm(3) (95% confidence interval 2, 14) per year among HSV-2-seropositive women compared with HSV-2-seronegative women. These data do not support a clinically meaningful effect of baseline HSV-2 seropositivity on the trajectories of HIV plasma viral loads or CD4 counts.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Herpes Genital
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Infecciones por VIH
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Herpesvirus Humano 2
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Epidemiol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos