Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 55(6): 3058-62, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21464254
ABSTRACT
Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics can make treatments less effective in some cases. We tested selected oligopeptoids--previously reported as mimics of natural host defense peptides--for activity against Mycobacterium tuberculosis and assessed their cytotoxicity. A tetrameric, alkylated, cationic peptoid (1-C13(4mer)) was most potent against M. tuberculosis and least cytotoxic, whereas an unalkylated analogue, peptoid 1(4mer), was inactive. Peptoid 1-C13(4mer) thus merits further study as a potential antituberculosis drug.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Peptoides
/
Antibacterianos
/
Mycobacterium tuberculosis
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos