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Antimycobacterial and synergistic effects of 18ß-glycyrrhetinic acid or glycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis.
Zhou, Xuezhang; Zhao, Li; Liu, Xiaoming; Li, Xueqiang; Jia, Fang; Zhang, Yuyan; Wang, Yujiong.
Afiliación
  • Zhou X; College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, China.
Phytother Res ; 26(2): 253-8, 2012 Feb.
Article en En | MEDLINE | ID: mdl-21656601
ABSTRACT
18ß-Glycyrrhetinic acid (18ßGA) is a major bioactive component of liquorice with known activity. In this study, we found that both 18ßGA and its derivative glycyrrhetinic acid-30-piperazine (PGA), have potent antimycobacterial properties against the drug-susceptible and drug-resistant Mycobacterium bovis. More importantly, they exhibited synergistic effects with the first-line drugs isoniazid (INH), rifampicin (RIF) and streptomycin (SM) against clinical M. bovis isolates, including drug-resistant strains. In combination with a subinhibitory concentration of 18ßGA, the minimum inhibitory concentrations (MICs) of the anti-tuberculosis agents decreased, ranging from 4- to 16-, 4- to 8- and 4- to 8-fold for INH (fractional inhibitory concentration index (FICI) 0.125-0.375), RIF (FICI 0.118-0.281) and SM (FICI 0.094-0.275), respectively. In the presence of PGA, MICs for the first-line agents resulted in a 4-16-fold decrease for INH (FICI 0.094-0.266, RIF (FICI 0.114-0.313) and SM (FICI 0.094-0.281). Additionally, the MICs of 18ßGA or PGA alone showed significant decreases ranging from 8- to 16-, 8- to 64- and 8- to 128-fold in the presence of INH, RIF and SM, respectively. These findings indicate that 18ßGA and its derivatives might serve as potential therapeutic compounds for future antimycobacterial drug development.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piperazinas / Ácido Glicirretínico / Mycobacterium bovis / Antituberculosos Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2012 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piperazinas / Ácido Glicirretínico / Mycobacterium bovis / Antituberculosos Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2012 Tipo del documento: Article País de afiliación: China