Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous.
Science
; 250(4986): 1370-7, 1990 Dec 07.
Article
en En
| MEDLINE
| ID: mdl-2175046
ABSTRACT
In the development of multicellular organisms a diversity of cell types differentiate at specific positions. Spacing patterns, in which an array of two or more cell types forms from a uniform field of cells, are a common feature of development. Identical precursor cells may adopt different fates because of competition and inhibition between them. Such a pattern in the developing Drosophila eye is the evenly spaced array of R8 cells, around which other cell types are subsequently recruited. Genetic studies suggest that the scabrous mutation disrupts a signal produced by R8 cells that inhibits other cells from also becoming R8 cells. The scabrous locus was cloned, and it appears to encode a secreted protein partly related to the beta and gamma chains of fibrinogen. It is proposed that the sca locus encodes a lateral inhibitor of R8 differentiation. The roles of the Drosophila EGF-receptor homologue (DER) and Notch genes in this process were also investigated.
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Bases de datos:
MEDLINE
Asunto principal:
Fibrinógeno
/
Glicoproteínas
/
Proteínas
/
Proteínas de Drosophila
/
Drosophila
/
Mutación
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1990
Tipo del documento:
Article