Short echo time single voxel 1H magnetic resonance spectroscopy in the diagnosis and characterisation of pineal tumours in children.
Pediatr Blood Cancer
; 57(6): 972-7, 2011 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-21793176
ABSTRACT
BACKGROUND:
Magnetic resonance spectroscopy (MRS) has been successful in characterising a range of brain tumours and is a useful aid to non-invasive diagnosis. The pineal region poses considerable surgical challenges and a major surgical resection is not required in the management of all tumours. Improved non-invasive assessment of pineal region tumours would be of considerable benefit.METHODS:
Single voxel MRS (TE 30 ms, TR 1500, 1.5 T) was performed on 15 pineal tumours 5 germinomas, 1 non-germinomatous secreting germ cell tumour (GCT), 2 teratomas, 5 pineoblastomas, 1 pineal parenchymal tumour (PPT) of intermediate differentiation and 1 pineocytoma. Two germinomas outside the pineal gland were also studied. Metabolite, lipid and macromolecule concentrations were determined with LCModel™.RESULTS:
Germ cell tumours had significantly higher lipid and macromolecule concentrations than other tumours (t-test; P < 0.05). The teratomas had significantly lower total choline and creatine levels than germinomas (z test; P < 0.05). Taurine was convincingly detected in germinomas as well as PPTs.CONCLUSIONS:
Magnetic resonance spectroscopy is useful for characterising pineal region tumours, aiding the non-invasive diagnosis and giving additional biological insight.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glándula Pineal
/
Pinealoma
/
Neoplasias Encefálicas
Tipo de estudio:
Diagnostic_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Blood Cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido