Sclerotherapy of abdominal lymphatic malformations with doxycycline.
J Vasc Interv Radiol
; 22(10): 1431-5, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21821431
ABSTRACT
PURPOSE:
To assess the safety and efficacy of percutaneous image-guided sclerotherapy with doxycycline as primary treatment of intraabdominal lymphatic malformations (LMs). MATERIALS ANDMETHODS:
Retrospective review was performed of all cases of abdominal, mesenteric, or retroperitoneal LMs referred to a single center that were subsequently treated with image-guided percutaneous sclerotherapy.RESULTS:
Ten patients were included, of whom six were male. The mean age was 13 years (range, 2-28 y). Preprocedural cross-sectional imaging demonstrated a macrocystic malformation in nine patients and a mixed macrocystic/microcystic malformation in one. The malformation was accessed under sonographic guidance, followed by injection of opacified sclerosant agent under fluoroscopic guidance. A drainage catheter was placed in eight cases, in which sclerotherapy was repeated through the catheter for another 1 day (n = 2) or 2 days (n = 6). Doxycycline was reconstituted at 10 mg/mL, with a mean per-session dose of 608 mg (range, 80-1,000 mg) and a mean total dose of 1,230 mg (range, 80-3,000 mg). Peritoneal spill was identified in one case, but the patient remained asymptomatic. No other complications were encountered. Follow-up imaging was available in eight patients complete resolution was seen in seven, with partial resolution in one. There was no recurrence of clinical symptoms in the follow-up period.CONCLUSIONS:
Initial results indicate that percutaneous image-guided sclerotherapy of macrocystic intraabdominal LMs with doxycycline is a safe and effective procedure.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Soluciones Esclerosantes
/
Escleroterapia
/
Doxiciclina
/
Anomalías Linfáticas
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Vasc Interv Radiol
Asunto de la revista:
ANGIOLOGIA
/
RADIOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos