Sesterterpenes from the tropical sponge Coscinoderma sp.
J Nat Prod
; 74(8): 1805-11, 2011 Aug 26.
Article
en En
| MEDLINE
| ID: mdl-21827183
ABSTRACT
Eight new sesterterpenes (2, 5, and 10-15), including structurally related pentaprenyl hydroquinones (2 and 5), and seven known ones of the same structural classes were isolated from the sponge Coscinoderma sp., collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and suvanine. These compounds exhibited moderate cytotoxicity against the K562 cell line and inhibitory activities against isocitrate lyase, sortase A, and Na+/K+-ATPase; significant structure-activity relationships were evident.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Poríferos
/
Sesterterpenos
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2011
Tipo del documento:
Article