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[Fetal and neonatal alloimmune thrombocytopenia]. / Føtal og neonatal alloimmun trombocytopeni er en mulig fatal tilstand.
Taaning, Ellen Birkerod Morling; Kjeldsen-Kragh, Jens; Hedegaard, Morten; Hegaard, Hanne Kristine; Henriksen, Tine Brink; Hvas, Anne-Mette; Kjærgaard, Hanne; Rasmussen, Ole Bredahl.
Afiliación
  • Taaning EB; Klinisk Immunologisk Afdeling, Vævstypelaboratoriet, Rigshospitalet, Tagensvej 20, 2200 København N, Denmark. ellen.morling.taaning@rh.regionh.dk
Ugeskr Laeger ; 173(34): 2041-4, 2011 Aug 22.
Article en Da | MEDLINE | ID: mdl-21867657
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) may lead to intracranial haemorrhage (ICH) resulting in neurological damage or death. In FNAIT, transplacental maternal antibodies cause destruction of fetal platelets. Maternal immunisation occurs to fetal human platelet antigens (HPAs) inherited from the father. In the absence of screening the diagnosis often relies on a serious incident in a previous pregnancy or in a newborn sibling. Thus, a future reduction in the risk of ICH depends on prospective large trials to evaluate different diagnostic, treatment, and prevention strategies.
Asunto(s)
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Bases de datos: MEDLINE Asunto principal: Trombocitopenia Neonatal Aloinmune Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies Límite: Female / Humans / Newborn / Pregnancy Idioma: Da Revista: Ugeskr Laeger Año: 2011 Tipo del documento: Article País de afiliación: Dinamarca
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Bases de datos: MEDLINE Asunto principal: Trombocitopenia Neonatal Aloinmune Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prognostic_studies Límite: Female / Humans / Newborn / Pregnancy Idioma: Da Revista: Ugeskr Laeger Año: 2011 Tipo del documento: Article País de afiliación: Dinamarca