TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I.
Science
; 333(6049): 1640-2, 2011 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-21921199
ABSTRACT
Transcription by eukaryotic RNA polymerases (Pols) II and III and archaeal Pol requires structurally related general transcription factors TFIIB, Brf1, and TFB, respectively, which are essential for polymerase recruitment and initiation events. A TFIIB-like protein was not evident in the Pol I basal transcription machinery. We report that TAF1B, a subunit of human Pol I basal transcription factor SL1, is structurally related to TFIIB/TFIIB-like proteins, through predicted amino-terminal zinc ribbon and cyclin-like fold domains. SL1, essential for Pol I recruitment to the ribosomal RNA gene promoter, also has an essential postpolymerase recruitment role, operating through TAF1B. Therefore, a TFIIB-related protein is implicated in preinitiation complex assembly and postpolymerase recruitment events in Pol I transcription, underscoring the parallels between eukaryotic Pol I, II, and III and archaeal transcription machineries.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
ARN Polimerasa I
/
Proteínas del Complejo de Iniciación de Transcripción Pol1
/
Factor de Transcripción TFIIB
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Science
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido