Relationship between fat mass and serum high-sensitivity C-reactive protein levels in prevalent hemodialysis patients.
Nephron Clin Pract
; 119(4): c283-8, 2011.
Article
en En
| MEDLINE
| ID: mdl-21921641
ABSTRACT
BACKGROUND/AIMS:
Little is known about the relationship between fat mass distribution and chronic inflammation in dialysis patients, in whom chronic inflammation is related to morbidity and mortality.METHODS:
The fat and lean masses (truncal and nontruncal) of 452 hemodialysis patients (age 64 ± 11 years; hemodialysis duration 89 ± 77 months; 37% diabetics) were measured by dual X-ray absorptiometry and their association with high-sensitivity C-reactive protein (hsCRP) was examined.RESULTS:
The fat mass of the high hsCRP group (n = 106) was significantly higher than that of the normal hsCRP group (n = 346; p < 0.05); there were no significant differences in lean mass between the two groups. Truncal fat mass of the former group was significantly greater than that of the latter (p < 0.05), but there was no significant difference in nontruncal fat mass between the two groups. In multiple regression analysis, truncal fat mass (ß = 0.227, p < 0.01) was significantly and independently associated with serum hsCRP levels after adjustment for age, gender and serum albumin (R(2) = 0.137, p < 0.01), whereas nontruncal fat mass was not.CONCLUSION:
Fat mass, particularly truncal fat mass, but not lean body mass, was significantly associated with serum hsCRP levels. The results suggest that truncal fat mass exhibits a distinct effect on chronic inflammation in hemodialysis patients.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteína C-Reactiva
/
Diálisis Renal
/
Adiposidad
/
Fallo Renal Crónico
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Nephron Clin Pract
Asunto de la revista:
NEFROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón