Seeking sense of antisense switch transcripts.
Transcription
; 2(4): 183-188, 2011 Jul.
Article
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| MEDLINE
| ID: mdl-21922061
ABSTRACT
In B lymphocytes, class switch recombination (CSR) machinery targets highly repetitive sequences, called switch (S) sequences, in the constant domain of the immunoglobulin heavy chain (IgH) locus. Cotranscriptional generation of R loops at S sequences provides the substrate for the mutagenic enzyme AID (Activation-Induced cytidine Deaminase), which initiates the DNA breaks at the transcribed sequences. Both sense and antisense transcripts across the S regions have been reported. Our recent work shows that, unlike its sense counterpart, antisense transcription of S sequences is dispensable for CSR in vivo.
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MEDLINE
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Año:
2011
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Article
País de afiliación:
Francia