A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.
PLoS One
; 6(10): e24431, 2011.
Article
en En
| MEDLINE
| ID: mdl-21984892
ABSTRACT
BACKGROUND:
In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes. METHODOLOGY/RESULTS:
Here, we demonstrate that CD55-deficient mice display a comparable phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen. This granulocytosis was independent of increased complement activity. Augmented numbers of Gr-1-positive cells in cell cycle in the bone marrow indicated a higher granulopoietic activity in mice lacking either CD55 or CD97. Concomitant with the increase in blood granulocyte numbers, Cd55â»/â» mice challenged with the respiratory pathogen Streptococcus pneumoniae developed less bacteremia and died later after infection.CONCLUSIONS:
Collectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Streptococcus pneumoniae
/
Antígenos CD55
/
Interacciones Huésped-Patógeno
/
Granulocitos
/
Homeostasis
Límite:
Animals
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Países Bajos