[Evaluation of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test in early diagnosis of cervical process].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 27(7): 801-2, 2011 Jul.
Article
en Zh
| MEDLINE
| ID: mdl-22031962
ABSTRACT
AIM:
To investigate the value of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test(TCT) in early diagnosis of cervical process.METHODS:
Patients(192) were investigated in the present study. TCT was used in all the patients. Immunohistochemistry was per-formed to examine the expressions of Brn-3a. The pathological results were used as the gold standard to evaluate the results of TCT method and Brn-3a in combination with LCT.RESULTS:
Compared with the pathological results, the accuracies of TCT method were 76.9% (30/39) , 80.5% (33/41)and 96.8% (30/31) in LSIL, HSIL, SCC respectively. The accuracies of Brn-3a in combination with TCT were 76. 9%(30/39), 78.6%(33/42) and 97.1% (30/31) in LSIL, HSIL and SCC respectively. The difference was significant in the diagnosis of LSIL and HSIL (P <0.05).CONCLUSION:
The detection of Brn-3a is of important clinic value in early diagnosis of cervical process.
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Bases de datos:
MEDLINE
Asunto principal:
Inmunohistoquímica
/
Neoplasias del Cuello Uterino
/
Factor de Transcripción Brn-3A
/
Detección Precoz del Cáncer
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
Zh
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
China