[Evaluation of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test in early diagnosis of cervical process].

ABSTRACT

AIM: To investigate the value of Brn-3a immunocytochemistry of liquid-based ThinPrep cytology test(TCT) in early diagnosis of cervical process. METHODS: Patients(192) were investigated in the present study. TCT was used in all the patients. Immunohistochemistry was per-formed to examine the expressions of Brn-3a. The pathological results were used as the gold standard to evaluate the results of TCT method and Brn-3a in combination with LCT. RESULTS: Compared with the pathological results, the accuracies of TCT method were 76.9% (30/39) , 80.5% (33/41)and 96.8% (30/31) in LSIL, HSIL, SCC respectively. The accuracies of Brn-3a in combination with TCT were 76. 9%(30/39), 78.6%(33/42) and 97.1% (30/31) in LSIL, HSIL and SCC respectively. The difference was significant in the diagnosis of LSIL and HSIL (P <0.05). CONCLUSION: The detection of Brn-3a is of important clinic value in early diagnosis of cervical process.